Lower Phosphoinositide 3-Kinase (PI 3-kinase) Activity and Differential Expression Levels of Selective Catalytic and Regulatory PI 3-Kinase Subunit Isoforms in Prefrontal Cortex and Hippocampus of Suicide Subjects
نویسندگان
چکیده
منابع مشابه
The phosphoinositide (PI) 3-kinase family.
Phosphoinositide (PI) 3-kinase was first observed in 1984 as a minor inositol lipid kinase activity associated with immunoprecipitated oncogene products (e.g. Src, Abl and polyoma mT antigen) and present in activated growth factor receptor complexes (e.g. PDGF receptor). In 1988, the enzyme associated with this activity was found to have the novel ability to phosphorylate the 3 position hydroxy...
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Phosphoinositide 3-Kinase (PI3K) is a central enzyme in a signaling pathway that mediates cellular responses to insulin and other growth factors. This enzyme phosphorylates the 3 position of phosphatidylinositol-4,5-bisphosphate to produce phosphatidyl-inositol-3,4,5-trisphosphate (PIP3) at the plasma membrane. A number of signaling proteins, including the Ser/Thr protein kinases, AKT and PDK1,...
متن کاملPI 3-kinase
When I was an undergraduate at Caltech, I worked in Bob Edgar’s laboratory on an obscure aspect of phage T4 morphogenesis, which had previously been studied by a little-known South African geneticist, Sydney Brenner [1]. I remember a journal club presented by one of the graduate students in the lab, about the lac repressor binding to DNA. I don’t remember the precise experiments but I know I wa...
متن کامل3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.
The recently discovered 3'-phosphoinositide-dependent kinase-1 (PDK-1) is a serine/threonine protein kinase which phosphorylates several members of the conserved AGC kinase superfamily (comprising the prototypes protein kinases A (PKA), G (PKG) and C (PKC)). Phosphorylation of a threonine or serine residue in the activation loop (also known as the T-loop) of these kinases is a critical step in ...
متن کاملEffect of IRS4 Levels on PI 3-Kinase Signalling
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood. IRS4 overexpression has been associated with acute lymphoblastic leukaemia and subungual exostosis, while point mutations of IRS4 have been found in melano...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2007
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1301641